Moroccan Merouane Zemmama makes his first start for Boro after joining in January?and replaces Julio Arca in midfield.
The other change sees Marvin Emnes come in for Scott McDonald, who misses out through illness.
Another notable name on the team sheet is Rhys Williams, who starts on the bench after 11 months out with a pelvic injury.
Reading: McCarthy; Mills, Gunnarsson, Khizanishvili, Harte; Tabb, Leigertwood, Robson-Kanu, Kebe; Long, Hunt.
Subs: Karacan, Antonio, Church, Howard, Morrison, Anderson, Manset.
Middlesbrough: Steele; McMahon, Grounds, Hines, Bennett; Bailey, Robson, Taylor, Zemmama; Emnes, Lita.
Subs: Ripley, Haas, Boyd, Kink, Halliday, Williams, Smallwood.
Source: Northern Echo
Source: Northern Echo