The tie will be played against Czech side Banik Ostrava at the Riverside on Thursday September 16 (KO 8pm).
The club has stressed that every season ticket holder will be able to claim their own seat for this historic occasion.
It has also been decided that season ticket holders will only pay the matchday equivalent price of their season ticket, providing a tremendous saving compared to Premier League match tickets.
Tickets for season ticket holders will be priced from £19 for adults and from £12 for those aged under-16 or over-65.
Season ticket holders have until Saturday September 11 to claim their own seat.
Seats go on sale from Saturday September 4 from the stadium ticket office, while postal applications are also acceptable.
As a number of seats at the Riverside are also available on a match-by-match basis, some tickets will also go on general sale from Saturday September 4 from the stadium ticket office.
Tickets for non-season ticket holders will be priced from £23 for adults and from £14 for those aged under-16 or over-65.
Any seats not claimed by season ticket holders by the closing date of Saturday September 11 will go on general sale from Monday September 13.
This is a game no Boro fan will want to miss, so season ticket holders are urged to claim their seat by the closing date.
Supporters applying by post should ensure they include with their application Voucher B, fully completed on the reverse, together with a stamped, self-addressed envelope.
Payment can be made by credit card/debit card or cheque made payable to Middlesbrough Football Club with a cheque guarantee card number written on the reverse.
Applications should be sent to: UEFA Cup Ticket Application, PO Box 1986, Middlesbrough FC, Riverside Stadium, Middlesbrough, TS3 6RS.
The full list of ticket prices are:
Season Ticket Non-Season Holders Ticket Holders
West Stand Upper Adults £28 31
Concessions £19 £22
West Stand Lower Adults £23 £26
Concessions £12 £14
East Stand Upper Adults £25 £30
Concessions £17 £19
East Stand Lower Adults £23 £26
Concessions £12 £14
North Stand Adults £19 £23
Concessions £12 £14
South Stand Adults £19 £23
Concessions £12 £14
NW Corner Adults £19 £23
Under-9’s £7 £14
Under-16’s £12 £14
16-21 £15 £23
Over-65’s £12 £14
SW Corner Adults £19 £23
Under-9’s £7 £14
Under-16’s £12 £14
16-21 £15 £23
Over-65’s £12 £14
*Concessions are for those aged under-16 or over-65.
Ticket details regarding the away leg on Thursday September 30 will be announced next week. However, the Club strongly advises supporters not to commit themselves to non-refundable air tickets without buying a ticket for the away leg first.
The club will be announcing details of official Travel Club arrangements at competitive rates in the near future.