The game kicks-off at 7pm at Vicarage Road.
The winners will play Tottenham or Everton, who also play tonight, at home in the sixth round.
Boro from:
Knight, Clough, Hines, Bates, Wheater, Burgess, Kennedy, Owens, Walker, Grounds, Cattermole, Johnson A, Craddock, Robets, Robson, Lemaire, Johnson J